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Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats
2021 NEJM): 1961 patients, 14.9% weight loss at 68 weeks
"A New Approach for Fast Metabolic Diagnostics in CMAMMA"
The G-protein coupled receptors activate phosphoinositide-specific phospholipase C (PLC)
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